L66P (p.Leu66Pro) variant of RAG1 (P15918)
L66P (p.Leu66Pro) in RAG1 (P15918) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
L66P (p.Leu66Pro) variant details
- p.Leu66Pro
- ExAC rs779859808
- gnomAD rs779859808
- Missense
- Variant Prioritization Score for Impact Estimate 0.117
- REVEL 0.09
- MetaLR 0.13
- MetaSVM -0.97
- CADD 4.46
- PolyPhen-2 0.00
- SIFT 0.49
- Most common in the Non-Finnish European population (allele frequency 9.9e-06)
- Structural context available