L59R (p.Leu59Arg) variant of RAG1 (P15918)
L59R (p.Leu59Arg) in RAG1 (P15918) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
L59R (p.Leu59Arg) variant details
- p.Leu59Arg
- gnomAD rs1157909558
- Missense
- Variant Prioritization Score for Impact Estimate 0.361
- REVEL 0.29
- MetaLR 0.30
- MetaSVM -0.68
- CADD 19.70
- PolyPhen-2 0.00
- SIFT 0.16
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available