H22Y (p.His22Tyr) variant of RAG1 (P15918)
H22Y (p.His22Tyr) in RAG1 (P15918) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
H22Y (p.His22Tyr) variant details
- p.His22Tyr
- TOPMed rs1319420569
- Missense
- Variant Prioritization Score for Impact Estimate 0.131
- REVEL 0.04
- MetaLR 0.14
- MetaSVM -1.03
- CADD 2.02
- PolyPhen-2 0.00
- SIFT 0.81
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available