L25* (p.Leu25Ter) variant of PTEN (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-)

Name: PTEN L25* (p.Leu25Ter) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-20
License: https://catvariant.com/terms-of-use

L25* (p.Leu25Ter) in PTEN (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-) is a protein-truncating change. Clinical records from EBI and UniProt describe it as pathogenic. The record also includes experimental measurements and structural context.

L25* (p.Leu25Ter) variant details

p.Leu25Ter
Ensembl rs786204912
Pathogenic
Stop Gained
EBI: Pathogenic
UniProt: Pathogenic
Structural context available
PTEN VAMP-seq Fill-in: score 0.103