I8T (p.Ile8Thr) variant of PTEN (P60484)
I8T (p.Ile8Thr) in PTEN (P60484) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.86 / 1. The record also includes structural context.
I8T (p.Ile8Thr) variant details
- p.Ile8Thr
- NCI-TCGA Cosmic COSV1044
- NCI-TCGA Cosmic COSV6429
- NCI-TCGA Cosmic COSV6430
- Ensembl rs2132145532
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.864
- ESM-1b 1.00
- AlphaMissense 0.70
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available