I8T (p.Ile8Thr) variant of PTEN (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-)

Name: PTEN I8T (p.Ile8Thr) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-20
License: https://catvariant.com/terms-of-use

I8T (p.Ile8Thr) in PTEN (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The record also includes structural context.

I8T (p.Ile8Thr) variant details

p.Ile8Thr
NCI-TCGA Cosmic COSV1044
NCI-TCGA Cosmic COSV6429
NCI-TCGA Cosmic COSV6430
Ensembl rs2132145532
Variant assessed as somatic; moderate impact.
Missense
UniProt: Variant assessed as somatic; moderate impact.
Structural context available