F21S (p.Phe21Ser) variant of PTEN (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-)

Name: PTEN F21S (p.Phe21Ser) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-20
License: https://catvariant.com/terms-of-use

F21S (p.Phe21Ser) in PTEN (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-) is a missense change. Clinical records from ClinVar and UniProt describe it as pathogenic in the context of not provided. The record also includes experimental measurements and structural context.

F21S (p.Phe21Ser) variant details

p.Phe21Ser
NCI-TCGA TCGA novel
Pathogenic
not provided
Missense
ClinVar: Pathogenic (not provided)
UniProt: Pathogenic
Structural context available
PTEN VAMP-seq Fill-in: score 0.838