R19C (p.Arg19Cys) variant of PRKCB (Protein kinase C beta type)
R19C (p.Arg19Cys) in PRKCB (Protein kinase C beta type) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.80 / 1. The record also includes population frequency data and structural context.
R19C (p.Arg19Cys) variant details
- p.Arg19Cys
- NCI-TCGA Cosmic COSV5776
- cosmic curated COSV57769
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.796
- CADD 32.00
- PolyPhen-2 0.97
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available