T121I (p.Thr121Ile) variant of PON1 (Serum paraoxonase/arylesterase 1)
T121I (p.Thr121Ile) in PON1 (Serum paraoxonase/arylesterase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
T121I (p.Thr121Ile) variant details
- p.Thr121Ile
- ESP rs147867887
- ExAC rs147867887
- TOPMed rs147867887
- gnomAD rs147867887
- Missense
- Variant Prioritization Score for Impact Estimate 0.12
- REVEL 0.02
- CADD 14.90
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Latino/Admixed American population (allele frequency 0.00013)
- Structural context available