S22Y (p.Ser22Tyr) variant of PON1 (Serum paraoxonase/arylesterase 1)
S22Y (p.Ser22Tyr) in PON1 (Serum paraoxonase/arylesterase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
S22Y (p.Ser22Tyr) variant details
- p.Ser22Tyr
- ExAC rs745880900
- TOPMed rs745880900
- gnomAD rs745880900
- Missense
- Variant Prioritization Score for Impact Estimate 0.261
- REVEL 0.12
- CADD 13.90
- PolyPhen-2 0.03
- SIFT 0.72
- Most common in the Latino/Admixed American population (allele frequency 0.00033)
- Structural context available