S22F (p.Ser22Phe) variant of PON1 (Serum paraoxonase/arylesterase 1)
S22F (p.Ser22Phe) in PON1 (Serum paraoxonase/arylesterase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
S22F (p.Ser22Phe) variant details
- p.Ser22Phe
- ExAC rs745880900
- TOPMed rs745880900
- gnomAD rs745880900
- Missense
- Variant Prioritization Score for Impact Estimate 0.253
- REVEL 0.10
- CADD 16.10
- PolyPhen-2 0.00
- SIFT 0.58
- Most common in the Ashkenazi Jewish population (allele frequency 0.0014)
- Structural context available