P59S (p.Pro59Ser) variant of PON1 (Serum paraoxonase/arylesterase 1)
P59S (p.Pro59Ser) in PON1 (Serum paraoxonase/arylesterase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
P59S (p.Pro59Ser) variant details
- p.Pro59Ser
- 1000Genomes rs199616322
- ExAC rs199616322
- TOPMed rs199616322
- gnomAD rs199616322
- Missense
- Variant Prioritization Score for Impact Estimate 0.252
- REVEL 0.10
- CADD 22.50
- PolyPhen-2 0.01
- SIFT 0.19
- Most common in the 1KG:FIN population (allele frequency 0.0051)
- Structural context available