L28F (p.Leu28Phe) variant of PON1 (Serum paraoxonase/arylesterase 1)
L28F (p.Leu28Phe) in PON1 (Serum paraoxonase/arylesterase 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.03 / 1. The record also includes population frequency data and structural context.
L28F (p.Leu28Phe) variant details
- p.Leu28Phe
- ExAC rs747905594
- TOPMed rs747905594
- gnomAD rs747905594
- Missense
- Variant Prioritization Score for Impact Estimate 0.0338
- REVEL 0.01
- CADD 0.30
- PolyPhen-2 0.00
- SIFT 0.31
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available