G21A (p.Gly21Ala) variant of POLD1 (P28340)
G21A (p.Gly21Ala) in POLD1 (P28340) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
G21A (p.Gly21Ala) variant details
- p.Gly21Ala
- NCI-TCGA TCGA novel
- Variant assessed as somatic; high impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.135
- REVEL 0.04
- CADD 11.10
- PolyPhen-2 0.01
- SIFT 0.15
- UniProt: Variant assessed as somatic; high impact. (in dbSNP:rs9282831)
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available