T41S (p.Thr41Ser) variant of PLP1 (Myelin proteolipid protein)
T41S (p.Thr41Ser) in PLP1 (Myelin proteolipid protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data and structural context.
T41S (p.Thr41Ser) variant details
- p.Thr41Ser
- TOPMed rs1005010589
- Missense
- Variant Prioritization Score for Impact Estimate 0.525
- AlphaMissense 0.10
- MetaLR 0.84
- MetaSVM 0.66
- CADD 17.60
- PolyPhen-2 0.01
- SIFT 1.00
- Most common in the 1KG:MXL population (allele frequency 0.0081)
- Structural context available