L31L (p.Leu31Leu) variant of PLP1 (Myelin proteolipid protein)
L31L (p.Leu31Leu) in PLP1 (Myelin proteolipid protein) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data, published literature, and structural context.
L31L (p.Leu31Leu) variant details
- p.Leu31Leu
- rs1391989749
- gnomAD X-103785668-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.512
- AlphaMissense 0.36
- MetaLR 0.98
- MetaSVM 1.09
- CADD 9.73
- PolyPhen-2 0.94
- SIFT 0.11
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00019)
- Structural context available
- Literature evidence available