E59D (p.Glu59Asp) variant of PLP1 (Myelin proteolipid protein)
E59D (p.Glu59Asp) in PLP1 (Myelin proteolipid protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
E59D (p.Glu59Asp) variant details
- p.Glu59Asp
- gnomAD rs1403370431
- Missense
- Variant Prioritization Score for Impact Estimate 0.506
- CADD 16.60
- PolyPhen-2 0.76
- SIFT 0.60
- Most common in the Middle Eastern population (allele frequency 0.0007)
- Structural context available