C25Y (p.Cys25Tyr) variant of PLP1 (Myelin proteolipid protein)
C25Y (p.Cys25Tyr) in PLP1 (Myelin proteolipid protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes population frequency data, published literature, and structural context.
C25Y (p.Cys25Tyr) variant details
- p.Cys25Tyr
- gnomAD X-103785651-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.709
- CADD 25.90
- PolyPhen-2 0.74
- SIFT 0.01
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available
- Literature evidence available