Y13S (p.Tyr13Ser) variant of PLCG2 (P16885)
Y13S (p.Tyr13Ser) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, experimental measurements, and structural context.
Y13S (p.Tyr13Ser) variant details
- p.Tyr13Ser
- gnomAD rs1261993965
- Missense
- Variant Prioritization Score for Impact Estimate 0.532
- CADD 24.20
- PolyPhen-2 0.94
- SIFT 0.19
- Most common in the Finnish in Finland (FIN) population (allele frequency 9.4e-05)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.0997