T3A (p.Thr3Ala) variant of PLCG2 (P16885)
T3A (p.Thr3Ala) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
T3A (p.Thr3Ala) variant details
- p.Thr3Ala
- gnomAD 16-81785996-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.0821
- CADD 1.92
- PolyPhen-2 0.00
- SIFT 0.64
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.0169
- Literature evidence available