T37S (p.Thr37Ser) variant of PLCG2 (P16885)
T37S (p.Thr37Ser) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T37S (p.Thr37Ser) variant details
- p.Thr37Ser
- ExAC rs765042969
- gnomAD rs765042969
- Missense
- Variant Prioritization Score for Impact Estimate 0.424
- CADD 21.00
- PolyPhen-2 0.00
- SIFT 0.10
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.301