T26K (p.Thr26Lys) variant of PLCG2 (P16885)
T26K (p.Thr26Lys) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
T26K (p.Thr26Lys) variant details
- p.Thr26Lys
- gnomAD 16-81786066-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.517
- CADD 23.30
- PolyPhen-2 0.03
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.121
- Literature evidence available