S55T (p.Ser55Thr) variant of PLCG2 (P16885)
S55T (p.Ser55Thr) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S55T (p.Ser55Thr) variant details
- p.Ser55Thr
- gnomAD 16-81786153-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.629
- CADD 22.40
- PolyPhen-2 0.01
- SIFT 0.48
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.287
- Literature evidence available