S32T (p.Ser32Thr) variant of PLCG2 (P16885)
S32T (p.Ser32Thr) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data, experimental measurements, and structural context.
S32T (p.Ser32Thr) variant details
- p.Ser32Thr
- gnomAD rs1238219389
- Missense
- Variant Prioritization Score for Impact Estimate 0.469
- CADD 22.20
- PolyPhen-2 0.12
- SIFT 0.26
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.278