R34R (p.Arg34Arg) variant of PLCG2 (P16885)
R34R (p.Arg34Arg) in PLCG2 (P16885) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
R34R (p.Arg34Arg) variant details
- p.Arg34Arg
- rs1319448998
- gnomAD 16-81786091-C-G
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.383
- CADD 9.28
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.164
- Literature evidence available