R34P (p.Arg34Pro) variant of PLCG2 (P16885)
R34P (p.Arg34Pro) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
R34P (p.Arg34Pro) variant details
- p.Arg34Pro
- gnomAD 16-81786090-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.746
- CADD 23.80
- PolyPhen-2 0.31
- SIFT 0.26
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.164
- Literature evidence available