L10P (p.Leu10Pro) variant of PLCG2 (P16885)
L10P (p.Leu10Pro) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L10P (p.Leu10Pro) variant details
- p.Leu10Pro
- gnomAD rs1234733197
- Missense
- Variant Prioritization Score for Impact Estimate 0.638
- CADD 25.60
- PolyPhen-2 0.90
- SIFT 0.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 1.9e-05)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.106