K35R (p.Lys35Arg) variant of PLCG2 (P16885)
K35R (p.Lys35Arg) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data, experimental measurements, and structural context.
K35R (p.Lys35Arg) variant details
- p.Lys35Arg
- ExAC rs759241889
- gnomAD rs759241889
- Missense
- Variant Prioritization Score for Impact Estimate 0.312
- CADD 22.20
- PolyPhen-2 0.01
- SIFT 0.38
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score 0.0593