K35N (p.Lys35Asn) variant of PLCG2 (P16885)
K35N (p.Lys35Asn) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
K35N (p.Lys35Asn) variant details
- p.Lys35Asn
- gnomAD 16-81786094-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.427
- CADD 25.00
- PolyPhen-2 0.56
- SIFT 0.00
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score 0.0593
- Literature evidence available