K15T (p.Lys15Thr) variant of PLCG2 (P16885)
K15T (p.Lys15Thr) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data, experimental measurements, and structural context.
K15T (p.Lys15Thr) variant details
- p.Lys15Thr
- TOPMed rs1050133080
- Missense
- Variant Prioritization Score for Impact Estimate 0.434
- CADD 24.20
- PolyPhen-2 0.96
- SIFT 0.47
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.254