I46I (p.Ile46Ile) variant of PLCG2 (P16885)
I46I (p.Ile46Ile) in PLCG2 (P16885) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
I46I (p.Ile46Ile) variant details
- p.Ile46Ile
- rs1023636697
- gnomAD 16-81786127-C-A
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.658
- CADD 12.70
- Population evidence available
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.223
- Literature evidence available