G25R (p.Gly25Arg) variant of PLCG2 (P16885)
G25R (p.Gly25Arg) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.82 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
G25R (p.Gly25Arg) variant details
- p.Gly25Arg
- gnomAD 16-81786062-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.824
- CADD 31.00
- PolyPhen-2 1.00
- SIFT 0.00
- Population evidence available
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.894
- Literature evidence available