F31L (p.Phe31Leu) variant of PLCG2 (P16885)
F31L (p.Phe31Leu) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data, experimental measurements, and structural context.
F31L (p.Phe31Leu) variant details
- p.Phe31Leu
- TOPMed rs1910956931
- Missense
- Variant Prioritization Score for Impact Estimate 0.522
- CADD 23.90
- PolyPhen-2 0.14
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.0504