A58T (p.Ala58Thr) variant of PLCG2 (P16885)
A58T (p.Ala58Thr) in PLCG2 (P16885) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
A58T (p.Ala58Thr) variant details
- p.Ala58Thr
- cosmic curated COSV63868
- ExAC rs766974268
- TOPMed rs766974268
- gnomAD rs766974268
- Missense
- Variant Prioritization Score for Impact Estimate 0.646
- CADD 22.90
- PolyPhen-2 0.34
- SIFT 0.36
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available