A21A (p.Ala21Ala) variant of PLCG2 (P16885)
A21A (p.Ala21Ala) in PLCG2 (P16885) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
A21A (p.Ala21Ala) variant details
- p.Ala21Ala
- rs374235189
- gnomAD 16-81786052-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.312
- CADD 8.68
- Most common in the African/African-American population (allele frequency 0.00048)
- Structural context available
- PLCG2 SH3 domain domainome 1.0: score -0.368
- Literature evidence available