W10* (p.Trp10Ter) variant of PCSK9 (Proprotein convertase subtilisin/kexin type 9)
W10* (p.Trp10Ter) in PCSK9 (Proprotein convertase subtilisin/kexin type 9) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
W10* (p.Trp10Ter) variant details
- p.Trp10Ter
- NCI-TCGA TCGA novel
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.421
- CADD 35.00
- UniProt: Variant assessed as somatic; high impact.
- Population evidence available
- Structural context available