P25T (p.Pro25Thr) variant of PCSK9 (Proprotein convertase subtilisin/kexin type 9)
P25T (p.Pro25Thr) in PCSK9 (Proprotein convertase subtilisin/kexin type 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, published literature, and structural context.
P25T (p.Pro25Thr) variant details
- p.Pro25Thr
- gnomAD 1-55039910-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.287
- REVEL 0.25
- ESM-1b 0.00
- AlphaMissense 0.09
- MetaLR 0.30
- MetaSVM -0.43
- CADD 15.60
- Population evidence available
- Structural context available
- Literature evidence available