L41P (p.Leu41Pro) variant of PCSK9 (Proprotein convertase subtilisin/kexin type 9)
L41P (p.Leu41Pro) in PCSK9 (Proprotein convertase subtilisin/kexin type 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, published literature, and structural context.
L41P (p.Leu41Pro) variant details
- p.Leu41Pro
- gnomAD 1-55039959-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.349
- REVEL 0.39
- ESM-1b 0.00
- AlphaMissense 0.15
- MetaLR 0.19
- MetaSVM -0.91
- CADD 24.00
- Population evidence available
- Structural context available
- Literature evidence available