L16P (p.Leu16Pro) variant of PCSK9 (Proprotein convertase subtilisin/kexin type 9)
L16P (p.Leu16Pro) in PCSK9 (Proprotein convertase subtilisin/kexin type 9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes structural context.
L16P (p.Leu16Pro) variant details
- p.Leu16Pro
- NCI-TCGA Cosmic COSV5616
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.206
- REVEL 0.17
- ESM-1b 0.00
- AlphaMissense 0.07
- MetaLR 0.17
- MetaSVM -1.02
- SIFT 0.08
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available