L15M (p.Leu15Met) variant of PCSK9 (Proprotein convertase subtilisin/kexin type 9)
L15M (p.Leu15Met) in PCSK9 (Proprotein convertase subtilisin/kexin type 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
L15M (p.Leu15Met) variant details
- p.Leu15Met
- gnomAD 1-55039880-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.301
- REVEL 0.18
- ESM-1b 1.00
- AlphaMissense 0.14
- MetaLR 0.26
- MetaSVM -0.68
- CADD 14.50
- Population evidence available
- Structural context available
- Literature evidence available