D35G (p.Asp35Gly) variant of PCSK9 (Proprotein convertase subtilisin/kexin type 9)
D35G (p.Asp35Gly) in PCSK9 (Proprotein convertase subtilisin/kexin type 9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes structural context.
D35G (p.Asp35Gly) variant details
- p.Asp35Gly
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.217
- REVEL 0.19
- ESM-1b 0.00
- AlphaMissense 0.09
- MetaLR 0.16
- MetaSVM -0.78
- SIFT 0.09
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available