T35I (p.Thr35Ile) variant of NRAS (GTPase NRas)
T35I (p.Thr35Ile) in NRAS (GTPase NRas) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.85 / 1. The record also includes population frequency data and structural context.
T35I (p.Thr35Ile) variant details
- p.Thr35Ile
- gnomAD rs1482529842
- Missense
- Variant Prioritization Score for Impact Estimate 0.849
- REVEL 0.88
- CADD 29.90
- PolyPhen-2 0.75
- SIFT 0.03
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)
- Structural context available