T2S (p.Thr2Ser) variant of NRAS (GTPase NRas)
T2S (p.Thr2Ser) in NRAS (GTPase NRas) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
T2S (p.Thr2Ser) variant details
- p.Thr2Ser
- Ensembl rs1659160002
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.377
- REVEL 0.27
- AlphaMissense 0.30
- MetaLR 0.08
- MetaSVM -1.02
- CADD 22.90
- PolyPhen-2 0.03
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Population evidence available
- Structural context available