Q25R (p.Gln25Arg) variant of NRAS (GTPase NRas)
Q25R (p.Gln25Arg) in NRAS (GTPase NRas) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
Q25R (p.Gln25Arg) variant details
- p.Gln25Arg
- rs2101744093
- ClinGen CA341742396
- ClinVar RCV001592708
- Ensembl rs2101744093
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.665
- REVEL 0.68
- CADD 27.60
- PolyPhen-2 0.46
- SIFT 0.04
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available