G13S (p.Gly13Ser) variant of NRAS (GTPase NRas)
G13S (p.Gly13Ser) in NRAS (GTPase NRas) is a missense change. Clinical records from EBI and UniProt describe it as pathogenic in the context of in CMNS and colorectal cancer. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes structural context.
G13S (p.Gly13Ser) variant details
- p.Gly13Ser
- rs121434595
- NCI-TCGA Cosmic COSV5473
- Pathogenic
- in CMNS and colorectal cancer
- Missense
- Variant Prioritization Score for Impact Estimate 0.585
- AlphaMissense 1.00
- MetaLR 0.56
- MetaSVM 0.13
- PolyPhen-2 1.00
- SIFT 0.00
- EVE 0.53
- EBI: Pathogenic (in CMNS and colorectal cancer)
- UniProt: Pathogenic (in CMNS and colorectal cancer)
- Structural context available