S35F (p.Ser35Phe) variant of MS4A1 (B-lymphocyte antigen CD20)
S35F (p.Ser35Phe) in MS4A1 (B-lymphocyte antigen CD20) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
S35F (p.Ser35Phe) variant details
- p.Ser35Phe
- ExAC rs762003025
- gnomAD rs762003025
- Missense
- Variant Prioritization Score for Impact Estimate 0.182
- REVEL 0.05
- MetaLR 0.09
- MetaSVM -1.01
- CADD 8.82
- PolyPhen-2 0.18
- SIFT 0.08
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available