L61I (p.Leu61Ile) variant of MS4A1 (B-lymphocyte antigen CD20)
L61I (p.Leu61Ile) in MS4A1 (B-lymphocyte antigen CD20) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data, published literature, and structural context.
L61I (p.Leu61Ile) variant details
- p.Leu61Ile
- gnomAD 11-60463023-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.306
- REVEL 0.21
- CADD 22.30
- PolyPhen-2 0.68
- SIFT 0.06
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available
- Literature evidence available