L37V (p.Leu37Val) variant of MS4A1 (B-lymphocyte antigen CD20)
L37V (p.Leu37Val) in MS4A1 (B-lymphocyte antigen CD20) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
L37V (p.Leu37Val) variant details
- p.Leu37Val
- NCI-TCGA Cosmic COSV1006
- cosmic curated COSV10061
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.103
- REVEL 0.09
- MetaLR 0.02
- MetaSVM -1.02
- CADD 0.00
- PolyPhen-2 0.00
- SIFT 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Middle Eastern population (allele frequency 0.0007)
- Structural context available