I21T (p.Ile21Thr) variant of MS4A1 (B-lymphocyte antigen CD20)
I21T (p.Ile21Thr) in MS4A1 (B-lymphocyte antigen CD20) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
I21T (p.Ile21Thr) variant details
- p.Ile21Thr
- gnomAD rs1230185096
- Missense
- Variant Prioritization Score for Impact Estimate 0.0791
- REVEL 0.03
- MetaLR 0.02
- MetaSVM -1.03
- CADD 3.28
- PolyPhen-2 0.00
- SIFT 0.55
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available