I21F (p.Ile21Phe) variant of MS4A1 (B-lymphocyte antigen CD20)
I21F (p.Ile21Phe) in MS4A1 (B-lymphocyte antigen CD20) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data and structural context.
I21F (p.Ile21Phe) variant details
- p.Ile21Phe
- ExAC rs755552110
- gnomAD rs755552110
- Missense
- Variant Prioritization Score for Impact Estimate 0.0723
- REVEL 0.02
- MetaLR 0.03
- MetaSVM -1.06
- CADD 2.48
- PolyPhen-2 0.08
- SIFT 0.16
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available