G19D (p.Gly19Asp) variant of MS4A1 (B-lymphocyte antigen CD20)
G19D (p.Gly19Asp) in MS4A1 (B-lymphocyte antigen CD20) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
G19D (p.Gly19Asp) variant details
- p.Gly19Asp
- rs1173252862
- NCI-TCGA Cosmic COSV1006
- cosmic curated COSV10061
- TOPMed rs1173252862
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.243
- REVEL 0.04
- MetaLR 0.09
- MetaSVM -1.05
- CADD 23.00
- PolyPhen-2 0.65
- SIFT 0.16
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00091)
- Structural context available